One major threat to cities at present is the increased inundation hazards owing to changes in climate and accelerated human activity. Future evolution of urban inundation is still an unsolved issue, given large uncertainties in future environmental conditions within urbanized areas. Developing model techniques and urban inundation projections are essential for inundation management. In this paper, we proposed a 2D hydrodynamic inundation model by coupling SWMM and LISFLOOD-FP models, and revealed how future urban inundation would evolve for different storms, sea level rise and subsidence scenarios based on the developed model. The Shiqiao Creek District (SCD) in Dongguan City was used as the case study. The model ability was validated against the June 13th, 2008 inundation event, which occurred in SCD, and proved capable of simulating dynamic urban inundation. Scenario analyses revealed a high degree of consistency in the inundation patterns among different storms, with larger magnitudes corresponding to greater return periods. Inundations across SCD generally vary as a function of storm intensity, but for lowlands or regions without drainage facilities inundations tend to aggravate over time. In riverfronts, inundations would exacerbate with sea level rise or subsidence; however, the inland inundations are seemingly insensitive to both factors. For the combined scenario of 100-yr storm, 0.5 m subsidence and 0.7 m sea level rise, the riverside inundations would occur much in advance, whilst catastrophic inundations sweep across SCD. Furthermore, the optimal low-impact development found for this case study includes 0.2 km2 of permeable pavements, 0.1 km2 of rain barrels and 0.7 km2 of green roofs.