Storm-centered infrared (IR) imagery of tropical cyclones (TCs) is related to the 850-hPa mean tangential wind at a radius of 500 km (V500) calculated from 6-hourly global numerical analyses for North Atlantic and eastern North Pacific TCs for 1995–2011. V500 estimates are scaled using the climatological vortex decay rate beyond 500 km to estimate the radius of 5 kt (1 kt = 0.514 m s-1) winds (R5) or TC size. A much larger historical record of TC-centered IR imagery (1978–2011) is then used to estimate TC sizes and form a global TC size climatology. The basin-specific distributions of TC size reveal that, among other things, the eastern North Pacific TC basins have the smallest while western North Pacific have the largest TC size distributions. The life cycle of TC sizes with respect to maximum intensity shows that TC growth characteristics are different among the individual TC basins, with the North Atlantic composites showing continued growth after maximum intensity. Small TCs are generally located at lower latitudes, westward steering, and preferred in seasons when environmental low-level vorticity is suppressed. Large TCs are generally located at higher latitudes, poleward steering, and preferred in enhanced low-level vorticity environments. Postmaximum intensity growth of TCs occurs in regions associated with enhanced baroclinicity and TC recurvature, while those that do not grow much are associated with west movement, erratic storm tracks, and landfall at or near the time of maximum intensity. With respect to climate change, no significant long-term trends are found in the dataset of TC size.