Aims: This paper presents a study on the development of a 2-dimensional (2D) hydrodynamic model based on TELEMAC-2D for the flood simulation of the river from Kratie to Kampong Cham in Cambodia, a part of the Mekong River. The motivation behind the research was to study the feasibility of TELEMAC-2D in flood forecasting, and specifically to determine its adequacy in flood simulations with a focus on the reduction in model run-time through parallelization. Place and Duration of Study: DHI-NTU Centre, Nanyang Environment and Water Research Institute (NEWRI), Nanyang Technological University, between November 2013 and March 2014. Methodology: We simulated an actual flood event which occurred between June to November in 2001 for the stretch of the Mekong River from Kratie to Kampong Cham and compared the model simulations with MODIS satellite Images for specific days in the pre-, peak- and post-flood period. Results: It was found that during the peak-flood period, there was high percentage (> 90%) match between the simulation results and observation obtained from satellite images while the match was below 50% for the pre- and post- flood periods. Conclusion: The 2D simulation results were consistent with observations from satellite imaging