This study aims to develop algorithm for generating high resolution DEM in an alluvial lowland area in the south of Danang city, Vietnam, where is suffering from high potential for flooding. An interpolation method using bi-cubic B-spline algorithm, namely BS-Horizon (Nonogaki et al., 2012), was used for generating high resolution DEM. BS_Horizon was evaluated as one of the highest accuracy method for generating DEM. This algorithm enables using elevation data as equality-inequality constraints on the surface. The optimal surface is the smoothest one that satisfy the given constraints (Nonogaki et al., 2012). The DEM interpolated from BS-Horizon was used as input data to determine the geomorphologic features and the relations on flood hazards of this low lying area. The landform classification is based on the topographical analysis and the land-cover of study area that extracted from ASTER remote sensed data. This geomorphologic delineation procedure was carried out in a floodplain, focusing on some inundated landform features such as: natural levees, flood basins, dry river beds, and former river channels. A flood susceptible map was built based on DEM data, landform and land-cover map of study area. The result was compared with past flood inundation map and flood prone map given by Danang city government to validate the flood hazard prediction map. This micro-landform mapping and flood susceptibility map is absolutely important for flood adaptive strategies in the lowland area in the south of Danang city where usually experiences with flood inundation.